Bradley T Hyman Selected Research

Amyloid Plaque

1/2021	Impairment of visual cortical plasticity by amyloid-beta species.
1/2019	Opposing Roles of apolipoprotein E in aging and neurodegeneration.
1/2018	Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
12/2016	Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.
2/2016	Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.
1/2016	Non-Fibrillar Oligomeric Amyloid-β within Synapses.
1/2016	Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.
1/2015	The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).
5/2014	Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.
4/2014	Mild to moderate Alzheimer dementia with insufficient neuropathological changes.

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Bradley T Hyman Research Topics

Disease

227	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2002
59	Amyloid Plaque 01/2021 - 01/2002
46	Parkinson Disease (Parkinson's Disease) 01/2021 - 05/2002
40	Dementia (Dementias) 01/2022 - 01/2002
32	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 05/2002
28	Cognitive Dysfunction 01/2022 - 09/2003
26	Tauopathies 12/2021 - 02/2007
10	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 01/2002
8	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2020 - 11/2007
8	Synucleinopathies 01/2020 - 05/2002
7	Gliosis 01/2018 - 03/2003
7	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 11/2015 - 07/2005
6	Disease Progression 01/2022 - 10/2014
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 07/2004
6	Atrophy 01/2017 - 03/2003
5	Neuroinflammatory Diseases 01/2022 - 11/2015
4	Inflammation (Inflammations) 01/2022 - 08/2004
4	Multiple System Atrophy 01/2020 - 05/2002
3	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2020 - 01/2002
3	Nervous System Diseases (Neurological Disorders) 09/2018 - 11/2011
3	Neoplasms (Cancer) 09/2018 - 05/2009
3	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2015 - 11/2007
3	Corticobasal Degeneration 11/2015 - 11/2007
2	Pathologic Processes 01/2021 - 05/2012
2	Memory Disorders (Memory Loss) 01/2016 - 08/2002
2	Amyloidosis 05/2014 - 10/2008
2	Cerebral Cortical Thinning 01/2014 - 03/2009
2	AIDS-Related Complex (ARC) 06/2012 - 07/2011
2	Hippocampal Sclerosis 01/2012 - 01/2012
2	Lewy Body Disease (Lewy Body Dementia) 01/2012 - 01/2012
2	Cerebrovascular Trauma 01/2012 - 01/2012
2	Neuroblastoma 03/2011 - 09/2008

Drug/Important Bio-Agent (IBA)

93	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2002
64	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2002
56	Amyloid beta-PeptidesIBA 01/2021 - 08/2002
28	alpha-SynucleinIBA 01/2014 - 05/2002
27	Apolipoproteins E (ApoE)IBA 01/2022 - 07/2002
26	tau Proteins (tau Protein)IBA 01/2022 - 11/2007
24	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2003
20	Peptides (Polypeptides)IBA 01/2022 - 01/2002
16	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2018 - 08/2002
15	SynucleinsIBA 01/2021 - 05/2002
13	ApolipoproteinsIBA 01/2021 - 07/2002
11	Protein Isoforms (Isoforms)IBA 12/2020 - 09/2003
9	Presenilin-1IBA 12/2021 - 03/2004
8	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020 - 01/2002
8	PresenilinsIBA 01/2017 - 01/2003
8	CaspasesIBA 01/2015 - 11/2002
7	CalciumIBA 01/2017 - 07/2008
6	UbiquitinIBA 01/2021 - 01/2008
6	Apolipoprotein E4IBA 01/2021 - 09/2003
6	EnzymesIBA 01/2015 - 09/2003
5	Carrier Proteins (Binding Protein)IBA 12/2021 - 10/2013
5	LigandsIBA 01/2021 - 01/2002
5	LipidsIBA 01/2021 - 10/2013
5	Messenger RNA (mRNA)IBA 07/2011 - 05/2006
4	AntioxidantsIBA 01/2022 - 03/2003
4	PrionsIBA 10/2021 - 06/2014
4	Pharmaceutical PreparationsIBA 01/2021 - 09/2009
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 03/2011
4	CholesterolIBA 01/2019 - 09/2004
4	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2015 - 01/2008
4	AntibodiesIBA 10/2014 - 05/2002
3	formic acid (formate)IBA 10/2021 - 05/2006
3	Protein AggregatesIBA 01/2021 - 01/2013
3	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2021 - 04/2012
3	CalcineurinIBA 10/2018 - 01/2012
3	Threonine (L-Threonine)FDA Link 02/2015 - 06/2002
3	ProgranulinsIBA 05/2014 - 01/2009
3	thioflavin TIBA 02/2014 - 03/2003
3	LDL Receptors (LDL Receptor)IBA 09/2008 - 07/2002
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 12/2010
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 10/2006
2	AcidsIBA 01/2021 - 09/2005
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2021 - 03/2005
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 02/2012
2	Caspase 3 (Caspase-3)IBA 01/2020 - 05/2006
2	Apolipoprotein E2IBA 01/2020 - 08/2005
2	CytokinesIBA 09/2018 - 11/2015
2	Doxycycline (Periostat)FDA LinkGeneric 01/2018 - 07/2011
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2017 - 01/2017
2	C-Reactive ProteinIBA 06/2015 - 06/2008
2	AutoantibodiesIBA 10/2014 - 04/2005
2	Immunoglobulin G (IgG)IBA 10/2014 - 11/2011
2	EpitopesIBA 10/2014 - 05/2011
2	Immunoglobulin M (IgM)IBA 10/2014 - 11/2011
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2014 - 04/2006
2	Carisoprodol (Soma)FDA LinkGeneric 02/2014 - 03/2003
2	PlasticsIBA 06/2012 - 03/2011
2	Coloring Agents (Dyes)IBA 11/2011 - 12/2005
2	Indicators and Reagents (Reagents)IBA 11/2011 - 09/2002
2	Contrast MediaIBA 11/2011 - 01/2006
2	Superoxide DismutaseIBA 11/2011 - 07/2004
2	Ginkgo biloba extract (Rokan)IBA 12/2010 - 11/2006
2	Peptide Hydrolases (Proteases)FDA Link 10/2010 - 10/2003
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2010 - 07/2005
2	Serine (L-Serine)FDA Link 11/2009 - 06/2002

Therapy/Procedure

23	Therapeutics 01/2022 - 09/2002
4	Immunotherapy 10/2014 - 01/2006
2	Activities of Daily Living (ADL) 01/2014 - 06/2008